Arid3b Is Critical for B Lymphocyte Development

Arid3b Is Critical for B Lymphocyte Development

Arid3a and Arid3b belong to a subfamily of ARID (AT-rich interaction domain) transcription factors. The Arid family is involved in regulating chromatin accessibility, proliferation, and differentiation. Arid3a and Arid3b are closely related and share a unique REKLES domain that mediates their homo- and hetero-multimerization. Arid3a was originally isolated as a B cell transcription factor bindi...

Lymphocyte Development — B- and T-Cell Development

I B I B deficiency reveals that a critical NF- B dosage is required for lymphocyte survival

In most cells, the NFB transcription factor is sequestered in the cytoplasm by interaction with inhibitory proteins, the I Bs. Here, we show that combined I B I B deficiency in mice leads to neonatal death, elevated B binding activity, overexpression of NFB target genes, and disruption of lymphocyte production. In I B I B -deficient fetuses, B220 IgM B cells and single-positive T cells die by a...

c-Myb is critical for B cell development and maintenance of follicular B cells.

The c-Myb transcription factor is crucial during definitive hematopoiesis. However, the embryonic lethality of Myb traditional null mutations has precluded analysis of c-Myb function in lymphocytes. Using tissue-specific inactivation at the Myb locus, we demonstrate that loss of Myb causes a partial block during B cell development at the pro-B to pre-B cell transition, resulting in greatly decr...

Apical ectodermal ridge morphogenesis in limb development is controlled by Arid3b-mediated regulation of cell movements.

The apical ectodermal ridge (AER) is a specialized epithelium located at the distal edge of the limb bud that directs outgrowth along the proximodistal axis. Although the molecular basis for its function is well known, the cellular mechanisms that lead to its maturation are not fully understood. Here, we show that Arid3b, a member of the ARID family of transcriptional regulators, is expressed i...